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Biolipidure Series
Contact Lens Raw Materials
Lipidure CM Series
Medical Nylon
Medical Silicone
Medical TPU
Medical Tube Extrusion
Silicone for Aerospace
Water soluble Urethane
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Lipidure¢ç-CM5206
Features Hemo-compatibility
Anti-adhesion of proteins and cells
Anti-denaturing of proteins
Anti-activation of cells
Usage Dissolve Lipidure¢ç-CM in ethanol and prepare a 0.5wt% ethanol solution.
Dip the base material into the coating solution for 1 min.
Dry the coated material at room temperature or one hour at 50ーC.
Substrates Lipidure¢ç-CM can be coated on the following substrates :
Plastics (PET, PMMA, PSt, PU, PC, PE, PP)
Glass, Ceramics and Metals (SUS, titanium, gold)
Lipidure-CM5206
m=3, n=7, Alkyl= n-Butyl
Lipidure-CM5206 is equivalent to ¡°PMB30¡±
in the Professors Nobuo Nakabayashi¡¯s and Kazuhiko Ishihara¡¯s literatures.
References
K. Ishihara, N. Nakabayashi et al., J. Biomed. Mater. Res. 28, 1347-1355(1994)
K. Ishihara, N. Nakabayashi et al., J. Biomed. Mater. Res. 39, 323-330(1998)
K. Ishihara, N. Nakabayashi et al., J. Biomed. Mater. Res. 64, 411-416(2003)
K. Nakabayashi, Macromol. Symp. 245-246, 591-598(2006)
£­Comparison of results£­
Experimental procedure
- Dispensation of HRP-IgG conjugate solution into each well
- Incubation for 1 h at 25¡ÆC
- Washing three times with Dulbeco¡¯ PBS including 0.05% of Tween20.
- Dispensation of 3,3¡¯,5,5¡¯ - tetramethylbenzidine solution
- Measurement of absorbance at 450 nm
The Lipidure¢ç treatment was able to reduce the amount of IgG absorption to below 10% of non-treated pleat. The same results were observed with other proteins
Experimental procedure
- Seeding of macrophage into each well (3.3 x 105 cells/well)
- Washing with Dulbeco¡¯ PBS
- Fixing with glutaraldehyde solution
- Observation by SEM
The activation and adhesion of macrophage was prevented by Lipidure¢ç treatment. Also, the Lipidure¢ç treatment was effective for other cells.
£­Coating£­
PC surface can be made by coating with Lipidure¢ç-CM. The following figure shows the relationship between ¡°he number of times the coating was applied¡±and ¡°he thickness of the coating film¡± The thickness of the Lipidure¢ç-CM coating film is calculated by weight measurement. These data are examples in the case of dip coating. The thickness was controlled by adjusting the number of times of a coating was applied and the concentration of Lipidure¢ç in the coating solution.
£­Safety Data£­
We have the following toxicological data for Lipidure¢ç-CM5206. Acute oral toxicity, Skin irritation, Skin sensitization, Mutagenic potential (Ames Test), Hemolysis test, Endotoxin test

Reactive Lipidure



Product Reactive Group X Packing Size Appearence
Lipidure NH01 NH2 10, 100g 5wt% aqueous solution
Lipidure CR2001 UV Curing 1, 10, 10g White powder
Lipidure CR3001 Alkoxy silane 1, 10, 10g White powder


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